Endocrine Abstracts

Patients with primary hyperparathyroidism (PHPT) are insulin resistant. The effect of PHPT on lipid levels and low-grade inflammation leves is unknown. The aim of our study was to estimate the cardiovascular risk profile in patients with PHPT. Methods: In patients with PHPT (N=19; age: 58.15±8.38 years; PTH 180.83±104.15 ng/l, calcium 2.97±0.19 mmol/l) insulin sensitivity (measured using euglycemic hyperinsulinemic clamp - M value), lipids (total choleste...

It was reported that patients with primary hyperparathyroidism (PHPT) are insulin resistant, and that surgical treatment may improve insulin sensitivity in this group of patients. The aim of our study was to evaluate the effect of surgical treatment on insulin sensitivity in patients with PHPT. Methods: In patients with PHPT (N=19; age: 58.15±8.38 years) insulin sensitivity was estimated using euglycemic hyperinsulinemic clamp (M value) before and 3 months after su...

It was shown that obesity and insulin resistance may influence ghrelin levels. Contraversial results were observed considering ghrelin levels in women with polycystic ovary syndrome (PCOS). The aim of our study was to investigate the basal ghrelin levels in obese patients with PCOS and to evaluate possible correlations between ghrelin levels, insulin resistance and, androgen levels. In 10 obese PCOS patients (BMI 32.50±1.57 kg/m2, age: 21.4±0.85 years) and...

It was speculated that androgen levels and insulin resistance may have influence on ghrelin levels. Elevated, normal and low ghrelin levels were reported in women with polycystic ovary syndrome (PCOS). The aim of our study was to investigate the basal ghrelin levels in lean patients with PCOS and to evaluate possible correlations between ghrelin levels, insulin resistance and, androgen levels. In 10 lean PCOS patients (BMI 20.45±0.51 kg/m2, age: 21.4±0.85 ...

Visfatin is expressed in visceral adipose tissue and is up regulated in some animal models of obesity. Insulin-mimetic actions of visfatin may be part of the feedback regulation of glucose homeostasis, so plasma glucose or insulin may have effect on visfatin levels in humans. The aim of study was to investigate plasma glucose, insulin and visfatin during oral glucose tolerance test (OGTT, 75 gr) in obese women. 22 obese women (age: 36.73±1.88 yrs; BMI 34.72±0.67 kg/m...

Visfatin, a new adipokine, facilitates adipogenesis and has insulin-mimetic properties. There are data that hyperglycemia causes an increase in plasma visfatin levels in people with T2DM this increase gets more prominent as the glucose intolerance worsens. The aim of the study was to investigate plasma visafatin, leptin and adiponectin in obese women with normal and impaired glucose tolerance. Thirteen obese women (age: 34.50±2.57 yrs; BMI 35.05±0.57 kg/m2) with norm...